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Disease entered English from French in the Middle Ages and originally meant “lack of ease,” hence inconvenience or trouble. It soon became associated specifically with illness, and the broader original sense disappeared in the 17th century.
Etymology
From Middle English disese, from Anglo-Norman desese, disaise, from Old French desaise, from des- + aise. Displaced native Middle English adle, audle (“disease”) (from Old English ādl (“disease, sickness”), see adle), Middle English cothe, coathe (“disease”) (from Old English coþu (“disease”), see coath). By surface analysis, dis- + ease.
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