inure comes from Middle English enuren, from the phrase in ure 'in use, in practice', where ure derives from Old French uevre 'work, practice', from Latin opera 'work'. The path is chiefly one of transmission: the word passes through the named languages and forms, with each stage preserving part of the modern shape. In present English, the verb sense is "to accustom someone to something unpleasant; to take effect (in law)", so the historical development ends in a clearly identifiable modern dictionary use. The same base also remains productive in derivatives such as inured and inurement. Its semantic neighborhood includes accustom, habituate, harden, and acclimatize, which helps locate the modern sense without adding a separate etymological claim. The named historical forms include Old French uevre and Latin opera.